When I first gave Creamy Buffalo Chicken Lasagna Roll Ups Recipe a try, I knew I had stumbled upon something truly special. Combining the addictive flavor of buffalo chicken with the comforting richness of lasagna, these little roll-ups are a feast for the senses.

Creamy, cheesy, spicy, and oh-so-satisfying, they’re easy enough to make on busy weeknights but impressive enough to wow at a potluck. Every bite is pure comfort food bliss rolled up and baked to golden perfection.

Ingredients for Perfect Lasagna Roll-Ups

Here’s a lineup of all the delicious ingredients you’ll need to make this flavor-packed dish.

12 lasagna noodles: Cook these until al dente so they’re easy to roll but maintain their shape.
3 cups shredded rotisserie chicken: Using rotisserie chicken saves time and adds great flavor.
8 ounces cream cheese, softened: Makes the filling extra creamy and smooth.
2 cups shredded mozzarella cheese: Half for the filling and half to create a gooey topping.
1 teaspoon garlic powder: Takes the filling’s seasoning to the next level.
½ teaspoon onion powder: Adds subtle depth to the flavor.
1 tablespoon chopped chives: Provides a fresh, mild onion-like kick.
½ teaspoon salt: Brings out all the savory goodness in the dish.
1½ cups Alfredo sauce: Acts as the creamy, rich base for the buffalo sauce.
½ cup Louisiana hot sauce: The star ingredient for that classic tangy buffalo flavor.

Note: This recipe makes about six servings. Double it for larger gatherings or super-hungry crowds!

Creative Variations to Try

This recipe is incredibly flexible, so feel free to make substitutions or add your own flair.

Meat Alternatives: Swap the chicken with shredded turkey or pulled pork for a different protein twist.
Cheese Upgrades: Use Monterey Jack, Colby, or pepper jack cheese to mix up the flavor.
Sauce Swap: Substitute barbecue sauce or even a mild mango habanero sauce for unique variations of this dish.
Low-Carb Option: Replace lasagna noodles with zucchini strips to cater to keto or low-carb diets.

Cooking Time Breakdown

This dish comes together quickly while delivering big on flavor! Here’s the time it takes:

Prep Time: 25 minutes
Cook Time: 30 minutes
Total Time: 55 minutes

Essential Equipment

Having these tools on hand will make cooking up your roll-ups a breeze!

Large pot: For boiling the lasagna noodles evenly.
Mixing bowls: To prepare the filling and combine the sauces.
Baking dish: Perfect for holding and baking the assembled roll-ups.
Foil: Keeps the roll-ups moist during the initial baking phase.

How to Make Creamy Buffalo Chicken Lasagna Roll-Ups?

This step-by-step guide will ensure your lasagna roll-ups are a smashing success.

Step 1: Cook and Cool the Noodles

Start by boiling 12 lasagna noodles in salted water until they’re al dente, usually 8–10 minutes. Drain the noodles and immediately lay them flat on parchment paper to cool. This prevents stickiness and tearing when it’s time to roll them up.

Step 2: Create the Chicken Filling

While the noodles cool, prepare the filling by combining shredded rotisserie chicken, softened cream cheese, 1 cup of mozzarella, garlic powder, onion powder, chives, and salt in a mixing bowl. Stir the ingredients together until smooth and evenly seasoned. The creamy filling is where the magic begins!

Step 3: Whip Up the Buffalo Alfredo Sauce

Whisk together the Alfredo sauce and buffalo sauce in a separate bowl until fully combined. This sauce will coat the roll-ups and bring that signature tangy heat we all love.

Step 4: Assemble the Roll-Ups

Spread a thin layer of the buffalo Alfredo sauce over the bottom of a greased baking dish. Take each lasagna noodle, spread a generous amount of chicken filling across its surface, and roll it up tightly. Place each roll-up seam-side down in the dish, nestled snugly together.

Step 5: Add Sauce and Cheese

Pour the remaining buffalo Alfredo sauce evenly over the roll-ups, ensuring every bite will be filled with creamy, spicy goodness. Sprinkle the remaining mozzarella cheese generously over the top to create that golden, bubbly crust.

Step 6: Bake to Perfection

Cover the baking dish loosely with foil and bake in a preheated oven at 375°F for 20 minutes. Then, remove the foil and bake for another 10 minutes to allow the cheese to melt and brown slightly. Once baked, garnish with fresh chives before serving.

Tips for Making the Perfect Roll-Ups

These simple tips will make your lasagna roll-ups even better!

Don’t Overcook the Noodles: Slightly undercooked noodles roll up more easily and won’t fall apart.
Spread the Sauces Generously: A well-coated dish ensures moist, flavorful roll-ups every time.
Homemade Alfredo Sauce: If you’ve got some extra time, making your own Alfredo sauce can elevate the dish even further.
Adjust the Spice: If you like mild dishes, reduce the amount of buffalo sauce slightly.

How to Serve Creamy Buffalo Chicken Lasagna Roll-Ups?

These roll-ups are perfect as both a main course and party appetizer! For a hearty meal, serve them alongside garlic bread and a crisp green salad. If you’re hosting a potluck, slice each roll into smaller pieces and serve with extra buffalo sauce or ranch dressing for dipping. They’re also amazing paired with roasted veggies for a comforting and balanced dinner.

Nutritional Information

Here’s a quick look at the nutritional breakdown per serving:

Calories: 987
Protein: 113g
Carbohydrates: 47g
Fat: 39g

Make Ahead and Storage

These roll-ups are perfect for busy weeks or prepping in advance.

Make Ahead

You can assemble the roll-ups up to three days ahead of time. Cover the dish tightly with plastic wrap and store it in the fridge until you’re ready to bake. Simply add 5–10 extra minutes to the baking time if starting from chilled.

Storage Tips

Leftovers can be stored in an airtight container in the fridge for 2–3 days. When reheating, use the oven at 350°F to preserve the texture and keep the cheese melty. For long-term storage, freeze the roll-ups in a freezer-safe dish for up to three months. Thaw overnight in the fridge before baking.

Why You’ll Love This Recipe?

Here are a few reasons that make these lasagna roll-ups a must-try:

Effortlessly flavorful with the bold tang of buffalo sauce and creamy Alfredo.
Quick to prepare using time-saving ingredients like rotisserie chicken.
Perfect for entertaining, with individual portions that look elegant and taste amazing.
Customizable to your taste, whether you prefer spicy, mild, or anything in between.
Great for meal prep, saving time and stress on busy days.

Creamy Buffalo Chicken Lasagna Roll-Ups are a game-changer for anyone who loves comfort food with a spicy twist. Whether you’re making them for a quiet family dinner or a lively dinner party, these roll-ups deliver bold flavors and hearty satisfaction every time. Try them out and watch them disappear from the table in no time!