First, preheat your oven to 375°F (190°C).
While the oven heats up, lightly grease your baking dish with cooking spray or a touch of olive oil.
Trim any excess fat from your chicken breasts and pat them dry with paper towels.
Take a mixing bowl and combine the mayonnaise, Parmesan cheese, garlic powder, onion powder, smoked paprika, salt, and pepper.
Mix everything together until smooth and creamy.
Place your chicken breasts into the greased baking dish in a single layer.
Spread the creamy mayo mixture over each chicken breast, making sure they’re evenly coated.
Pop the baking dish into your preheated oven and bake for 45 minutes.
Use a meat thermometer to ensure the chicken has reached an internal temperature of 165°F (74°C).
If you’d like the topping slightly crispy, turn on the broiler for the last 2 minutes.
Once the chicken is done, remove it from the oven and let it rest for about 5 minutes. This helps the juices redistribute, keeping the chicken tender and moist.